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 Session Abstract – PMWC 2026 Silicon Valley

Track 4: Integrated PM - March 6 9.00 A.M.-4.15 P.M.


Track Chair:
Alex Zhavoronkov, Insilico Medicine

PMWC Award Ceremony
• Steve Horvath, UCLA
• David Sinclair, Harvard
• Nir Barzilai, Albert Einstein College of Medicine

AI & Biomarkers for Measuring Aging
• Chair: Alex Zhavoronkov, Insilico Medicine
• Luigi Ferrucci, NIH
• Sara Hägg, Karolinska Institutet
• Steve Horvath, UCLA

Epigenetic Rejuvenation & Delivery for Clinical Translation
• Ryan (Yuancheng) Lu, Whitehead Institute / MIT
• David Sinclair, Harvard

Clinical Trial Design & Functional Endpoints for Healthspan
• Nir Barzilai, Albert Einstein

Precision Aging & Longevity Focused on Limited Lifespan Evidence, Vanishing Blue Zones, and Payer ROI
• S. Jay Olshansky, University of Illinois

 Speaker Profile

Ph.D., Professor, Karolinska Inst.t

Biography
Associate professor in molecular epidemiology at the Department of Medical Epidemiology and Biostatistics at Karolinska Institutet and my research is about aging. I use data from the Swedish Twin Registry and the UK Biobank to look at biological aging and associations with age-related diseases.


 Speaker Profile

M.D., Ph.D., Senior Investigator, NIH-NIA

Biography
Dr. Luigi Ferrucci is a geriatrician and an epidemiologist who conducts research on the causal pathways leading to progressive physical and cognitive decline in older persons. In September 2002, he became the Chief of the Longitudinal Studies Section at NIA and the Director of the Baltimore Longitudinal Study on Aging. Medical Degree and Board Certification in 1980, Board Certification in Geriatrics in 1982 and Ph.D. in Biology and Pathophysiology of Aging in 1998 at the University of Florence, Italy. Principal Investigator of the InCHIANTI study and of the Baltimore Longitudinal Study on Aging. Dr. Ferrucci is Scientific Director, NIA since May 2011.


 Speaker Profile

Ph.D., Executive Director, External Strategy and Partnerships, Buck Insititute/Price Lab

Biography
Yi Sherry Zhang is a genomics scientist and health-tech entrepreneur advancing the translation of longevity science into scalable population impact. At the Buck Institute for Research on Aging, she leads the development of Healthspan Horizons, a federated AI and biodata platform integrating multi-omics, digital, and clinical signals to quantify and extend healthy human lifespan. Drawing on nearly two decades of experience at the intersection of molecular science, data intelligence, and personalized health, she previously founded GenoPalate, which built one of the worlds largest nutrigenomics databases and consumer platforms for precision nutrition. Her work bridges molecular biomarkers and actionable lifestyle insights, with publications and features spanning scientific and public domains. An advocate for equitable access to scientific wellness, she speaks globally on data federation, precision aging, and the future of healthspan intelligence.


 Speaker Profile

Professor, Harvard

Biography
David A. Sinclair, A.O., Ph.D. is considered one of the worlds most influential scientists and a leading figure in the study of human longevity. He is a tenured Professor of Genetics at Harvard Medical School (Boston, MA, USA) and Co-Founder Co-Chief Editor of the scientific journal Aging.Professor Sinclairs pioneering work in genetics and aging biology has fundamentally shaped the worlds understanding of mechanisms of aging and age-related diseases. He is best known for his research on the molecular biology of aging, particularly the role of sirtuins, NAD+ metabolism, and epigenetic changes in regulating the aging process. In 2020, the Sinclair Lab reported successful use of cellular reprogramming to safely reverse aging in mammals, which they showed could cure blindness in animal models.Professor Sinclair served as Founding Director of the Glenn Center for Biology of Aging Research at Harvard Medical School from 2004 2023 and has published over 400 articles that have been cited 100,000 times. He is the inventor on more than 50 patents and has co-founded over a dozen successful companies including MetroBiotech, EdenRoc Sciences, Fully Aligned Company, and Life Biosciences.Professor Sinclair is the New York Times bestselling author of Lifespan: Why We Age-And Why We Dont Have To and the host of the Lifespan with Dr. David Sinclair podcast, a 1 show on Apple that provides health and science education.Among over 35 career awards, Professor Sinclair has been recognized as one of TIME Magazines 100 Most Influential People In The World, one of TIMEs 50 Most Influential People In Health Care, received the Pioneer Award from the Director of the NIH, The Noble Genius Prize from The World Forum, and was appointed by Queen Elizabeths representative as Officer of the Order of Australia(A.O.) for his contributions to scientific research, science communication, and national security.


 Speaker Profile

M.D., Director, Institute for Aging Research; President, Academy for Health and Lifespan Research., Albert Einstein College of Medicine

Biography
Dr. Nir Barzilai is a preeminent leader in geroscience, demonstrating in his studies that aginghas its own biology that drives age-related diseases, a process that can be targeted. At AlbertEinstein College of Medicine, he is a professor in the departments of Medicine and Genetics,the director of the Institute for Aging Research, and the director of the Einstein-NationalInstitutes of Health (NIH) Nathan Shock Center of Excellence in the Basic Biology of Aging, andthe author of 350 papers. He made seminal discoveries in extending the health and lifespan ofanimals and discovering pathways for exceptional longevity in humans. He is leading aninternational effort to approve drugs targeting aging. Targeting Aging with Metformin (TAME) isa specific study conceived by Dr. Barzilai to prove that a single drug can combat multiplediseases associated with aging and get FDA approval for targeting aging. Dr. Barzilai is a co-founder and the President of AHLS. He is also on the board of directors of the AmericanFederation for Aging Research, where he co-leads its biomarker effort (FAST), TAME, andSuper Agers initiative. He is an Executive of the Longevity Biotech Association (LBA) andserves on the Healthy Longevity Medicine Society council. He authored Age Later: Health Span,Life Span, and the New Science of Longevity.


 Speaker Profile

Ph.D., Principal Investigator, Altos Labs

Biography
Dr. Steve Horvath is a geroscientist and computational biologist best known for developing the epigenetic clock, a groundbreaking biomarker that measures biological aging based on DNA methylation patterns. His work has transformed aging research, enabling precise tracking of aging-related interventions and influencing diagnostics, longevity science, and precision medicine. Dr. Horvath has led key studies linking epigenetic age acceleration to disease risk and mortality, paving the way for potential anti-aging therapies. He has held leadership roles in major scientific initiatives and has received numerous honors, including election to the Academy for Health Lifespan Research, as well as the Nathan W. Shock Award for aging research. His contributions continue to shape the future of aging and longevity research, with broad applications in medicine and biotechnology.


 Speaker Profile

Ph.D., CEO, Insilico Medicine

Biography
Alex Zhavoronkov, PhD, is the founder and CEO of Insilico Medicine, a leading clinical-stage biotechnology company developing next-generation generative artificial intelligence and robotics platforms for drug discovery. Under his leadership, Insilico raised over $400 million in multiple rounds from expert biotechnology, healthcare, and financial investors, opened RD centers in 6 countries and regions, and partnered with multiple pharmaceutical, biotechnology, and academic institutions. Since 2021, the company nominated 21 preclinical candidates, started 6 human clinical trials, and entered Phase II with an AI-discovered novel target and AI-designed novel molecule. Since 2012, he has published over 200 peer-reviewed research papers and 3 books. He is the adjunct professor of artificial intelligence at the Buck Institute for Research on Aging.


 Speaker Profile

Ph.D., Professor, San Francisco State

Biography
Dr. Goldman did his undergraduate work in Biology at the University of Rochester, and obtained a Ph.D. in evolutionary biology at Purdue University in 1981. Turning to human genetics, Dr. Goldman completed two fellowships in Medical Genetics, one at Baylor College of Medicine in Houston, the other at the University of Washington in Seattle. Dr. Goldman joined the faculty at San Francisco State University in 1988, where Dr. Goldman am currently Professor and Former Chair of the Department of Biology. Currently Dr. Goldman serve the Chair of the University Academic Senate. Dr. Goldman have taught general genetics and evolution for biology majors, developmental biology for Cell Molecular Biology majors, and an interdisciplinary course on the ethical issues in science and technology. My research is in chromatin structure and the regulation of gene expression during mammalian development. Of special interest is the relationship between chromosome structural elements called nuclear matrix attachment regions (MARs) as boundaries of functional chromatin domains, studied through molecular methods and bioinformatics. Dr. Goldman see the public understanding of science as a key need if science and society are to thrive. Dr. Goldman speak to professional and general groups whenever possible, and Ive talked about various issues like stem cell biology for TV and radio call-in audiences. Dr. Goldman have written Op-Ed pieces or letters for the Los Angeles Times, the Wall Street Journal, the Sacramento Bee, the San Francisco Chronicle and the New York Times, as well as a variety of technical articles, including those appearing in Science and Nature Genetics. Dr. Goldman have been Associate Editor for Chromosome Research and a contributing editor to Bio-IT World. Dr. Goldman think the public learns much about science and bioethics from fiction, and Dr. Goldman review novels addressing various aspects of genetic science and its implications, in venues like Nature, Science, Nature Genetics and the San Francisco Chronicle.


 Speaker Profile

Ph.D., Professor, Buck Inst.

Biography
Nathan Price focuses on advancing AI-enabled scientific wellness and bringing precision medicine into proactive practice. His work integrates multi-omics, digital biomarkers, and computational modeling to detect early signals of aging, resilience, and diseaseand to translate them into personalized, actionable guidance. He is building next-generation AI platforms designed to operationalize precision health at scale.Price has authored 220 scientific publications and led landmark longitudinal wellness studies. He co-authored The Age of Scientific Wellness. He has written for major outlets including The Wall Street Journal, LA Times, and Scientific American, and been a guest on leading podcasts such as Armchair Expert, The Doctors Farmacy, and Keeping It Real with Jillian Michaels. His recognitions include being an Emerging Leader for the National Academy of Medicine, service on the National Academies Board on Life Sciences, Fellowship in AIMBE, and the 2023 Alexander Mildred Seelig Award from the American Nutrition Association.


 Speaker Profile

Ph.D., Professor, UC Santa Barbara

Biography
Professor Gurven's research links the evolved life history of humans with high levels of intragroup cooperation. He has conducted fieldwork for two decades with South American indigenous populations, and his work takes an evolutionary perspective on behavior, health, physiology and psychology. Since 2002, Gurven has co-directed the Tsimane Health and Life History Project to better understand how aspects of environment and lifestyle affect health and lifespan in subsistence-level societies. His research applies an evolutionary lens to help inform our understanding of todays complex diseases. His current research in biodemography and health disparities helps understand environmental and social impacts on growth, development and aging across the lifespan. He also focuses on how acculturation and market integration have impacted demographic and social patterns, and chronic disease risk (e.g. heart disease, diabetes, dementia) among indigenous populations.


 Speaker Profile

M.D., Lecturer, UC Berkeley

Biography
Dr. Tony Iton is a Lecturer of Health Policy Management at UC Berkeleys School of Public Health. He is also a Senior Vice President for Healthy Communities at The California Endowment. In the fall of 2009, he began to oversee the organizations 10-Year, multimillion-dollar statewide commitment to advance policies and forge partnerships to build healthy communities and a healthy California. Iton serves on the board of directors of the Public Health Institute, the Public Health Trust, the Prevention Institute and Jobs For The Future. In the past, he has served as both the director and County Health Officer for the Alameda County Public Health Department. In that role, he oversaw the creation of an innovative public health practice designed to eliminate health disparities by tackling the root causes of poor health that limit the quality of life and lifespan in many of Californias lowincome communities. He has worked as an HIV disability rights attorney at the Berkeley Community Law Center, a health care policy analyst with Consumers Union West Coast Regional Office, and as a physician and advocate for the homeless at the San Francisco Public Health Department.Dr. Itons primary focus includes health of disadvantaged populations and the contributions of race, class, wealth, education, geography and employment to health status. His awards include the Champion of Children Award from the United Way and the National Association of City and County Health Officials Award of Excellence for the use of information technology in public health. In February 2010, Dr. Iton was recognized by the California Legislative Black Caucus with the Black History Month Legends Award and presented on the floor of the California State Assembly with a resolution memorializing his lifes work and achievements.


 Speaker Profile

Ph.D., Head of Bioinformatics, TruDiagnostic

Biography
Varun Dwaraka is a bioinformatics researcher specializing in epigenetics and machine learning. He leads a team at TruDiagnostic which implements machine learning methods to identify epigenetic biomarkers, and generate predictive algorithms, which help understand the molecular biology of aging. These tools are then used to investigate associations of aging to an individual's disease, and overall mortality, risk. His work has been published in numerous peer reviewed publications, and has been patented. His work has been featured in periodicals (e.g., Forbes), documentaries (e.g., HBO and Netflix), and podcasts (e.g., Alldus International). In 2020, Dr. Dwaraka was elected as a full member to the Sigma Xi, The Scientific Research Honor Society, and served as a 2023 Foresight Fellow in Biotechnology and Health Expansion, awarded by the Foresight Institute. He also serves on Scientific Advisory Boards for various entities (e.g., SRW Labs) to which he offers insight into the application and interpretation of epigenetic age biomarkers.


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