Speaker Profile

PhD, CSO and Co-Founder, Prism AI

Orly Alter is a USTAR associate professor at the Scientific Computing and Imaging Institute and the Huntsman Cancer Institute at the University of Utah, a scientific advisory board member of the NCI-DOE Cancer Moonshot collaboration on predictive oncology, and the CSO and a co-founder of Prism AI. Her Ph.D. thesis in applied physics at Stanford University is recognized as crucial to quantum computing. Inventor of the “eigengene," Alter develops AI/ML to compare and integrate datasets of any types, number and dimensions, and sizes. She demonstrated that her algorithms, the multi-tensor comparative spectral decompositions, discover interpretable and actionable predictors, applicable to the general population from as few as 50–100 patients, and her predictors outperform all others, where they exist. Her retrospective clinical trial experimentally validated a genome-wide pattern in brain cancer tumors as the most accurate and precise predictor of life expectancy and response to standard of care.

AI-Powered Biomarker Discovery for Personalized Medicine
The ability to detect complex multi-omic differential signatures is the basis for personalized medicine. But with typical AI this process rarely converges into an effective solution. We will present a powerful and novel AI approach for the discovery of biomarkers and drug targets from real-life, small-cohort, multi-omic, and noisy data.

Clinical & Research Tools Showcase:
Prism AI

Prism AI offers an AI-first clinical multi-omic data management and analytics platform that allows biotech companies and health systems to unlock the potential of their own data and create the next generation of drugs and biomarkers.

 Session Abstract – PMWC 2024 Silicon Valley

Track 4 - January 26 9.00 A.M.-4.00 P.M.

Track Chair: Stacey Gabriel, Broad Institute and Steve Turner, PacBio

  • New Frontiers in Genomic Analysis & Interpretation
    - Robert Sebra, ISMMS
    - Anshul Kundaje, Stanford
    - Chaz Langelier, UCSF
    - Orly Alter, Prism AI Inc
  • From Potential to Reality: Bringing Nanopore Sequencing to Clinical Practice (PANEL)
    Chair: Emma Stanton, Oxford Nanopore Tech - Charles Chiu, UCSF
    - Billy Tsz Cheong Lau, Stanford
  • Population Sequencing at Scale: Impact and Future Path of Genomic Programs (PANEL)
    Chair: Stacey Gabriel, Broad Institute
    - Heidi Rehm, MGH
    - Cindy Lawley, Olink
    - John M. Gaziano, Million Veterans Program (MVP)
  • New Frontiers in Genomic Analysis & Interpretation continues: AI in Spatial Transcriptomics in Patient Response
    - David. W. Craig, City of Hope Cancer Center
    - Premal Shah, MyOme
  • The Economic Perspective on Genomics (PANEL)
    Chair: Bill Hyun, UCSF
    - Steve Turner, PacBio
    - Alex de Winter, Danaher Ventures
    - Kandaswamy (Swamy) Vijayan, Zafrens
  • Using AI for Scalable Phenotyping and Discovery
    - Andrew Carroll, Google
  • Building Bridges: Precision Medicine Communities
    - Kumar Prashant, Karkinos
  • NCI Showcase
    - Xiaofeng Xie, MicrOmics Technologies


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