Speaker Profile
DSc, Vice President, Amgen
Biography
Brian is a global expert in pharmacoepidemiology and real-world data (RWD), with over 25 years of experience in industry and academia. At Amgen, he leads a team of over 150 professionalsincluding epidemiologists, biostatisticians, and data scientistsfocused on generating high-quality real-world evidence (RWE) to inform healthcare decision-making and support patient care. His team has conducted research across multiple countries, addressing drug safety, effectiveness, supporting regulatory approvals and post-marketing safety commitments, and describing disease burden and unmet need.Brian oversaw the development of Amgen's global RWD platform, housing data on more than 350 million lives, and successfully integrated the FDA Sentinel System to enhance safety surveillance efforts. He is an Adjunct Professor of Epidemiology at UCLA and has authored over 90 peer-reviewed publications on pharmacoepidemiology, disease epidemiology, and advanced methods for controlling confounding in drug safety research.
Talk
Accelerating Drug Development with Real-World Evidence and AI: Amgen's Journey
Session Abstract – PMWC 2025 Silicon Valley
Track Chair:
- William Oh, Yale Cancer Center
Patient-centric data, such as Real-World Evidence (RWE) and Real-World Data (RWD), has become critical in reshaping drug development and healthcare decision-making. Over the last few years, regulatory agencies like the FDA and EMA have increasingly embraced RWE/RWD for decision-making processes, influencing everything from new drug indications to post-marketing surveillance. The integration of RWE and RWD is not only supporting clinical trial design and regulatory approvals, but also enabling precision medicine by providing deeper insights into patient subpopulations and their outcomes
Sessions:
- PMWC 2025 Award Ceremony
Pioneer Honoree: Isaac Kohane, Harvard
- Keynote: Can AI succeed where humans have failed to personalize medicine?
- Isaac Kohane, Harvard
- From Data to Decisions: Real-Time Patient Insights for Improved Care (PANEL)
Chair: Michael Pfeffer, Stanford Medicine
- Chris Longhurst, UC San Diego Health
- Tanya Townsend, Stanford Children’s
- Kiran Mysore, Sutter Health
- Cherodeep Goswami, UW Health - AI-Powered RWE: Driving Trustworthy Insights and Innovation through Interoperability (PANEL)
Chair: Charles Jaffe, HL7 International
- Chris Longhurst, UC San Diego Health
- Donald Rucker, 1upHealth
- Stan Huff, Graphite Health
- John Ioannidis, Stanford
- Chris Boone, Oracle
- Accelerating Drug Development with Real World Evidence and AI: Amgen's Journey
- Brian Bradbury, Amgen
- AI-Powered RWE: Accelerating Drug Development and Post-Market Applications (PANEL)
Chair: Erik Reinertsen, Demand Discovery Group
- Michelle Chen, Insilico Medicine
- Jun Jeon, Khosla Ventures
- Dan Riskin, Verantos
- Andrew Trister, Verily - Advancing Patient-Centered Outcomes with AI and Real-World Data Integration
- Phil Johnson, Evidation Health
- Leveraging AI and Real-World Evidence to Transform Patient Care in Oncology
- Amrita Basu, UCSF
- How to Implement AI for Faster Readout of Clinical Trails
Chair:William Oh, Yale
- Jennifer Webster, Pfizer
- Brandon Allgood, Parabilis Medicines
- Julian Hong, UCSF
- Michiel Niesen, nference
