Speaker Profile
M.D., Ph.D., Global Development & Clinical Lead, Pfizer
Biography
Dr. Meng Li is a physician-scientist by training. He brings a rare combination of scientific depth and clinical development leadership, with more than a decade of experience advancing early- and late-stage oncology programs across the pharmaceutical industry. He is widely recognized for his contributions to cancer genomics, liquid biopsy, and novel therapeutics.
His research has contributed to the discovery of multiple human cancer genes, including ARID1A, ARID2, MLL2, MLL3, and BCORL1. He is also an inventor of BEAMing technology, which leverages circulating tumor DNA for cancer detection, disease stratification, and monitoring of treatment response. His work has helped shape modern oncology practice, and he has published as a lead author in prestigious journals, including Science, Nature Genetics, Nature Medicine, Nature Biotechnology, Nature Methods, and Blood. He has also been a driving force in targeting epigenetic machinery and advancing novel immunotherapies for the treatment of human cancer.
Talk
Targeting Epigenetics for Cancer Diagnosis and Treatment
Prifetrastat is a novel, selective catalytic inhibitor of KAT6A&B. In a phase 1/2 trial, prifetrastat in combination with fulvestrant demonstrated promising antitumor activity and an acceptable safety profile in patients with HR-positive, HER2-negative metastatic breast cancer These findings establish KAT6A&B as druggable cancer targets, provide clinical proof of concept, and reveal a new therapeutic avenue.
Emerging Therapeutics Showcase:
Pfizer
Pfizer is an american multinational pharmaceutical and biotechnology corporation. Pfizer develops medicine and vaccines for immunology, oncology and general medicine.
Session Abstract – PMWC 2027 Silicon Valley
The PMWC 2027 Emerging Therapeutics Showcase will provide a 15-30 minute time slot for selected companies and researchers in the CRISPR, Cell and Gene Therapy fields. Major advancements in safer cell- and gene-level editing technologies are bringing us closer toward cures for life-threatening disorders, from cancer to HIV to Huntington’s disease. Cell therapy, in which cellular material such as T cells capable of fighting cancer cells, is injected into a patient, has been demonstrated safe and effective. The popular new CRISPR tool that has been used to edit the genetic code of nearly any organism will have an enormous impact on human health. More than a dozen clinical trials employing CRISPR on human cells are already underway.
- Emerging Therapeutics/Cell Therapy
- Emerging Therapeutics/CVD
- Emerging Therapeutics/Gene Therapy
- Emerging Therapeutics/Immunotherapy
- Emerging Therapeutics/Radiation Therapy
PMWC Hall of Impact
Previous Speakers Include
Nobel laureates, technology founders, regulators, CEOs and scientific pioneers who have taken the PMWC stage.
