The diagnosis, risk stratification, and treatment of cancer have become increasingly personalized. Clinicians utilize novel testing technologies to select targeted therapeutics based on predictive biomarkers. The advent of newer and less invasive approaches to diagnosis such as liquid biopsy is enabling clinicians to better tailor treatment plans for their patients. Novel immunotherapy agents used alone or in combination with other agents may further optimize outcomes for patients with advanced disease. This session will explore the unique challenges that community-based clinicians face in their practice.