Speaker Profile

PhD, Director, Computational and Structural Biology, Outpace Bio

Biography
Dr. Weitzner leads a world class team at Outpace Bio that combines protein design, machine learning and custom software to create mechanism driven solutions to dramatically improve the efficacy and safety of cell and gene therapies. Brian co founded OpenFold in 2022 to democratize AI for biology and enable new cures to come to market that would be impossible to discover without AI. Before co founding Outpace in 2020, Brian conducted his doctoral work with Jeff Gray at the Johns Hopkins University and studied protein design with David Baker as a WRF Innovation Fellow at the Institute for Protein Design at the University of Washington. Brian has been a core developer and leader in the Rosetta Commons for over 15 years where he develops physics based protein modeling methods and trains the next generation of protein designers. Brian made the jump to industry in 2018 as one the first scientists to join Lyell Immunopharma.


Talk
Creating Cell Therapies for Solid Tumors with Protein Design
Cell therapies have the potential to cure a wide array of diseases but have not been successful when targeting solid tumors, the vast majority of cancers. We leverage knowledge about the underlying molecular basis of these limitations to design proteinbased interventions to harness the full potential of cellular medicines and break free from default biology.


 Session Abstract – PMWC 2024 Silicon Valley

Track 1 - January 25 9.00 A.M.-4.30 P.M.


Track Chair: Sharon Benzeno, Adaptive Biotechnologies

  • PMWC 2024 Award Ceremony
    Pioneer Honoree: Stanley Riddell, Fred Hutchinson
    Pioneer Honoree: George Coukos, Ludwig Cancer Center
  • Keynote: Engineering Synthetic T Cell States for Cancer Rejection
    - George Coukos, Ludwig Cancer Center
  • Discovery of Novel Targets in Cell Therapies in Oncology and Autoimmune Disorders (PANEL)
    Chair: Harlan Robins, Adaptive Bio
    - Stanley Riddell, Fred Hutchinson
    - Allison Betof Warner, Stanford
    - Lawrence Fong, UCSF
  • Supply Chain 2.0 Getting Cell Therapies to Patients (PANEL)
    Chair: Jean Xu, Janssen Pharmaceuticals
    - Amanda Pace, Sonoma Bio
    - Laura Deschenes, Sana Biotechnology
  • Evolving Case Law and Practical Strategies for Immunotherapy Patents
    - Janet Xiao, Morrison & Foerster LLP
  • Emerging Clinical Data in Oncology Cell Therapeutics
    Chair: Andrew Allen, Gritstone bio, Inc.
    - Robert Meehan, Moderna
  • Scientific Advancements in Individualized Cell Therapies in Oncology ( PANEL)
    Chair: Sharon Benzeno, Adaptive Biotechnologies
    - Ira Mellman, Genenetch
    - Robert Meehan, Moderna
    - Dirk Nagorsen, Affini-T Therapeutics
  • AI-Enhanced Approaches in Cell Therapy Development
    Chair: Suchit Jhunjhunwala, Genentech
    - Brian Weitzner, Outpace Bio
  • PMWC Showcase
    - Arun Wiita, UCSF

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