Alexandre Loupy

Biography
Alexandre Loupy is an internationally recognized physician-scientist who has transformed how transplant rejection and long-term graft survival are characterized and predicted. He is at the head of the Paris Institute for Transplantation & Organ Regeneration, where he has built large, deeply characterized cohorts integrating clinical, biological, immunologic, histologic, and transcriptomic data. He led the development of iBox, a prediction system that combines kidney function, proteinuria, donor-specific antibodies, and biopsy findings to estimate an individual patient's risk of kidney-allograft loss. The system was developed and validated in 7,557 recipients across 10 centers in Europe and North America and confirmed in three randomized clinical trials. It has received regulatory qualification in Europe and a favorable FDA qualification opinion for transplant clinical trials. Loupy has also applied machine learning and molecular profiling to identify distinct rejection phenotypes and improve transplant diagnostics. His work extends beyond kidney transplantation to heart-transplant rejection and pig-to-human xenotransplantation.