Speaker Profile
PMWC PIONEER AWARD
Developed iBox and redefined transplant rejection through data-driven pathology
M.D., Ph.D., Professor of Nephrology and Head of the PITOR Institute, APHP - UPC - Inserm
Biography
Alexandre Loupy is an internationally recognized physician-scientist who has transformed how transplant rejection and long-term graft survival are characterized and predicted. He is at the head of the Paris Institute for Transplantation & Organ Regeneration, where he has built large, deeply characterized cohorts integrating clinical, biological, immunologic, histologic, and transcriptomic data. He led the development of iBox, a prediction system that combines kidney function, proteinuria, donor-specific antibodies, and biopsy findings to estimate an individual patient's risk of kidney-allograft loss. The system was developed and validated in 7,557 recipients across 10 centers in Europe and North America and confirmed in three randomized clinical trials. It has received regulatory qualification in Europe and a favorable FDA qualification opinion for transplant clinical trials. Loupy has also applied machine learning and molecular profiling to identify distinct rejection phenotypes and improve transplant diagnostics. His work extends beyond kidney transplantation to heart-transplant rejection and pig-to-human xenotransplantation.
Session Abstract – PMWC 2027 Silicon Valley
Track Chair:
Christina Curtis, Stanford
PMWC Award Ceremony
• Joe DeRisi, UCSF / CZ Biohub / Delve Bio (Luminary)
• Alexandre Loupy, Inserm / Paris Transplant Group (Pioneer)
Featured Speakers
• Joe DeRisi, UCSF / CZ Biohub / Delve Bio
• Alexandre Loupy, Inserm / Paris Transplant Group
• Minnie Sarwal, UCSF
• Kiran Khush, Stanford
• Iwijn De Vlaminck, Cornell
• Maarten Naesens, KU Leuven
• Charles Chiu, UCSF
• Michael Snyder, Stanford
• Duncan MacCannell, CDC
• Chaz Langelier, UCSF
• Yoel Sadovsky, Stanford
• Ananth Karumanchi, Cedars-Sinai
• Gabriel Bien-Willner, Palmetto GBA / MolDX
• Dawn Cardeiro, Roche Diagnostics
• Bruce Quinn, Bruce Quinn Associates
Transplant & Organ Health Diagnostics
From biopsy to blood-based monitoring of rejection, injury, and infection.
Blood-Based Omics and Host Response in Infection
Metagenomics and host-response signals for difficult infectious disease cases.
Maternal & Fetal Health
From prenatal screening to actionable maternal and placental biomarkers.
From Signal to Standard of Care
What makes a non-cancer blood test clinically actionable and reimbursable.
PMWC Hall of Impact
Previous Speakers Include
Nobel laureates, technology founders, regulators, CEOs and scientific pioneers who have taken the PMWC stage.
