Speaker Profile
PMWC PIONEER AWARD
Pioneered gamma entrainment as a new path for precision neurology
Ph.D., Picower Professor of Neuroscience, MIT
Biography
Professor Li-Huei Tsai is the Picower Professor of Neuroscience at the Department of Brain and Cognitive Sciences and a member of the Picower Institute for Learning and Memory, at the Massachusetts Institute of Technology. She pioneered the use of non-invasive sensory stimulation to treat Alzheimer’s disease and other neurological disorders. Tsai is a Fellow of the American Association for the Advancement of Science, a Fellow of the National Academy of Inventors, a Member of the National Academy of Medicine, an Academician of the Academia Sinica in Taiwan, and a Member of the American Academy of Arts and Sciences. She is a recipient of the Mika Salpeter Lifetime Achievement Award, the 2018 Hans Wigzell Research Foundation Science Prize for her research on Alzheimer’s disease, and 2025 Distinguished Lecturer for Parkinson’s Disease Research, Helis Medical Research Foundations. In 2022 she was named a Visiting Professor of the Vallee Foundation.
Talk
Sensory Gamma Stimulation in Neuroprotection/Treating Alzheimer’s
Gamma oscillations (30–80 Hz) support cognition and are disrupted in Alzheimer’s disease. We developed GENUS, delivering 40 Hz light and sound, which increases gamma power, reduces pathology, and improves cognition in mouse models. GENUS also alters glia and vasculature, enhancing glymphatic clearance via cholinergic and neuropeptide signaling underlying neuroprotection mechanisms.
Session Abstract – PMWC 2027 Silicon Valley
Track Chair:
David Liebeskind, UCLA
PMWC Award Ceremony
• Li-Huei Tsai, MIT Picower Institute (Pioneer)
• Thomas C. Südhof, Stanford (Nobel Laureate, Pioneer)
• David Holtzman, WashU (Pioneer)
• Henrik Zetterberg, UCL / Gothenburg (Luminary)
Featured Speakers
• Thomas C. Südhof, Stanford
• Li-Huei Tsai, MIT Picower Institute
• David Holtzman, WashU
• Henrik Zetterberg, UCL / Gothenburg
• Mark Mintun, Lilly
• Randall Bateman, WashU
• Nikolaos Mellios, Circular Genomics
• Robert Rissman, USC
• Lynn Kramer, Eisai
• Thomas F. Tropea, University of Pennsylvania
• Ari J. Green, UCSF
• Diane Chan, Mass General Brigham
• Leslie Shaw, University of Pennsylvania
• Prashanthi Vemuri, Mayo Clinic
• Kejal Kantarci, Mayo Clinic
• Dan Huddleston, Lightbox Science
• Patrick Brannelly, 10K Brains
• Allan Levey, Emory
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From biomarker to bedside across neurological disease.
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Parkinson's, ALS, and FTD in the precision era.
AI & Imaging Across Neurological Disease
Precision phenotyping in stroke, epilepsy, and neurodegeneration.
Why Precision Neurology Is Not Scaling
The evidence, infrastructure, access, and workflow barriers that must be fixed.
Harnessing Brain Rhythms
Gamma oscillations, brain circuits, and the future of neurotherapy.
PMWC Hall of Impact
Previous Speakers Include
Nobel laureates, technology founders, regulators, CEOs and scientific pioneers who have taken the PMWC stage.
