Speaker Profile
PMWC PIONEER AWARD
Pioneered gamma entrainment as a new path for precision neurology
Ph.D., Picower Professor of Neuroscience, MIT
Biography
Professor Li-Huei Tsai is the Picower Professor of Neuroscience at the Department of Brain and Cognitive Sciences and a member of the Picower Institute for Learning and Memory, at the Massachusetts Institute of Technology. She pioneered the use of non-invasive sensory stimulation to treat Alzheimer’s disease and other neurological disorders. Tsai is a Fellow of the American Association for the Advancement of Science, a Fellow of the National Academy of Inventors, a Member of the National Academy of Medicine, an Academician of the Academia Sinica in Taiwan, and a Member of the American Academy of Arts and Sciences. She is a recipient of the Mika Salpeter Lifetime Achievement Award, the 2018 Hans Wigzell Research Foundation Science Prize for her research on Alzheimer’s disease, and 2025 Distinguished Lecturer for Parkinson’s Disease Research, Helis Medical Research Foundations. In 2022 she was named a Visiting Professor of the Vallee Foundation.
Talk
Sensory Gamma Stimulation in Neuroprotection/Treating Alzheimer’s
Gamma oscillations (30–80 Hz) support cognition and are disrupted in Alzheimer’s disease. We developed GENUS, delivering 40 Hz light and sound, which increases gamma power, reduces pathology, and improves cognition in mouse models. GENUS also alters glia and vasculature, enhancing glymphatic clearance via cholinergic and neuropeptide signaling underlying neuroprotection mechanisms.
Session Abstract – PMWC 2027 Silicon Valley
Davos of Precision Medicine
PMWC 2027 Program
January 27–29, 2027 · Santa Clara Convention Center
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