Speaker Profile

PMWC PIONEER AWARD
Developed a new and reliable technique for diagnosing Alzheimer’s disease and measuring the efficacy of experimental treatments

M.D., Ph.D., John Douglas French Alzheimer Foundation Endowed Professor, UCSF

Biography
Dr. Lea Tenenholz Grinberg is a neuropathologist specializing in brain aging, most notably, Alzheimer’s diseases. She is a Full Professor and a John Douglas French Alzheimer’s Foundation Endowed Professor at the UCSF Memory and Aging Center, where she co-led the Neuropathology Core. She is also a Professor of Pathology at the University of Sao Paulo. Dr. Grinberg is the recipient of several awards and have co-authored over 260 scientific papers. The Grinberg Lab investigates factors influencing clinical expression of Alzheimer’s pathology and other tauopathies to lead to better diagnostic tools and therapeutic targets that minimize clinical decline in AD by following up on Dr. Grinberg’s initial discoveries of brainstem vulnerability in Alzheimer’s disease. Her discoveries had changed the understanding on the basis of sleep disturbances in these diseases. The Lab combines classical quantitative neuropathological techniques with advanced computer vision tools and multiplex molecular probing in postmortem human tissue


Talk
Unveiling the Basis of Neuroimaging Signal with Histology
neuroimaging findings is often based on assumptions because of its lower resolution compared to microscopy. We developed a computational and histological pipeline to process and stain whole human brain volumes, 3D reconstruct the histological volume at microscopical level and perfectly align histology-based cytoarchitectonic and protein deposition 3D maps to their neuroimaging counterparts.


 Session Abstract – PMWC 2023 Silicon Valley

Track 4 - January 27 9.00 A.M.-3.00 P.M.


Track Chair: Sean Khozin, CancerLinQ

  • PMWC Award Ceremony:
    Pioneer Honoree: Daniela Ushizima, LBNL, UCSF, UCB & Lea Grinberg, UCSF
  • Pattern Recognition and Content Quantification in Early-stage Disease Diagnosis (PANEL)
    Chair: Daniela Ushizima, LBNL, UCSF, UCB
    - Lea Grinberg, UCSF
    - Suzanne Baker, LBL
  • Second Phase of AI Imaging is Clinical Validation
    - Sean Khozin, CancerLinQ
  • Large-Scale Spatial Omics Imaging Analysis To Decipher The Tumor Microenvironment
    - Joseph Lehar, Owkin
  • Latest Achievement in AI Imaging Technology in the area of Radiology and Pathology
    Chair: Lars Coster, Icometrix
    - Joachim H. Schmid, NanoString Technologies
    - Fedaa Najdawi, PathAI
    - Nurit Paz Yaacov, Imagene
    - Neil Weisenfeld, 10x
  • AI in Radiology & Pathology Applications (Clinical Research)
    Chair: Mirabela Rusu, Stanford
    - Saeed Hassanpour, Dartmouth
    - Jeanne Shen, Stanford
    - Pratik Mukherjee, UCSF
  • PMWC NCI Showcase
    - Omid Moghadam, Rapid
  • PMWC Showcase
    - Amanda Hanson, Spartanburg Regional Healthcare System

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