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 Speaker Profile

PMWC PIONEER AWARD
Pioneered chemical biology and targeted protein degradation for precision therapeutics

M.D., EVP R&D, Amgen

Biography
Dr. James "Jay" Bradner is executive vice president, Research and Development. He is responsible for advancing Amgen's pipeline, which includes potential first-in-class or best-in-class medicines in all stages of development across the company's four therapeutic areas of focus: oncology, inflammation, general medicine and rare disease, in addition to biosimilars. He is also responsible for Amgen's worldwide research efforts. Prior to joining Amgen, Dr. Bradner served as President of the Novartis Institutes for BioMedical Research, where he was a member of the Executive Committee of Novartis. His research and leadership have contributed to numerous development programs, multiple investigational new drug applications and positive proof-of-concept studies in clinical investigation. He also has been a clinician at the Dana-Farber Cancer Institute and an associate professor at Harvard Medical School. As an entrepreneur, he co-founded and built several biotechnology startups. Additionally, he has co-authored dozens of scientific publications and is a named inventor on numerous U.S. patent applications. Dr. Bradner is a graduate of Harvard College and the University of Chicago Medical School. He completed his residency in Medicine at Brigham & Women's Hospital, his fellowship in Medical Oncology and Hematology at the Dana-Farber Harvard Cancer Center, and his postdoctoral training in Chemistry and Chemical Biology at Harvard University.


 Session Abstract – PMWC 2027 Silicon Valley

Track 1: Next-Gen Tx - Jan 29 9.00 A.M.-4.30 P.M.


Track Chair:
Catriona Jamieson, UC San Diego

PMWC Award Ceremony
• Emmanuelle Charpentier, Max Planck (J. Craig Venter Visionary Award · Nobel Laureate)
• Jay Bradner, Amgen (Pioneer)
• Adrian Krainer, Cold Spring Harbor Laboratory (Luminary)
• Randy Schekman, UC Berkeley (Nobel Laureate, Pioneer)

Featured Speakers
• Emmanuelle Charpentier, Max Planck
• Randy Schekman, UC Berkeley
• Jay Bradner, Amgen
• Adrian Krainer, Cold Spring Harbor Laboratory
• Alexis C. Komor, UC San Diego
• Nicole Gaudelli, GV
• Rachel Haurwitz, Caribou Bio
• Gene Yeo, UC San Diego
• Timothy Yu, Boston Children's / Harvard
• Shicheng Guo, Arrowhead Pharmaceuticals
• Mark A. Kay, Stanford
• Niren Murthy, UC Berkeley
• Ben Deverman, Broad Institute
• Stanley Crooke, n-Lorem / Ionis

Programming Protein Fate
Molecular glues, degraders, and induced proximity crossing into medicines.

Genome Editing Beyond the First Wave
Base, prime, and CRISPR-enabled editing moving from correction to clinic.

RNA Editing, Splice Modulation & Programmable RNA
RNA editing, ASOs, and splice modulation with chemistry already reaching patients.

In Vivo Delivery & Vector Engineering
AAV, LNP, and next-generation vectors that decide what is treatable.

From N-of-1 to Platform
Evidence, CMC, regulation, and access for individualized genetic medicines.

PMWC 2027 Silicon Valley - Program

PMWC Hall of Impact

Previous Speakers Include

Nobel laureates, technology founders, regulators, CEOs and scientific pioneers who have taken the PMWC stage.

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