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 Speaker Profile

PMWC PIONEER AWARD
Pioneered chemical biology and targeted protein degradation for precision therapeutics

M.D., EVP R&D, AI&D, Amgen

Biography
Dr. James "Jay" Bradner joined Amgen in 2023 and currently serves as Executive Vice President, Research & Development, Artificial Intelligence & Data. He leads the company's global Research and Development organization, integrating biology, data science, and artificial intelligence to accelerate the discovery and development of innovative medicines. Under his leadership, Amgen is advancing a diverse pipeline of potential first- and best-in-class therapies across oncology, inflammation, general medicine, rare disease, and biosimilars. Immediately before joining Amgen, Dr. Bradner returned to clinical service as a stem cell transplant physician at the Dana-Farber Cancer Institute and Brigham & Women’s Hospital. He also taught at Harvard Business School and MIT, and served as an advisor to Blackstone Life Sciences and Isomorphic Labs (Alphabet, Google DeepMind). He previously served as President of the Novartis Institutes for BioMedical Research, where he was a member of the Executive Committee of Novartis. During his tenure, he built and led a highly productive research organization that combined advanced therapeutic platforms, large-scale data science and global scientific talent to drive innovation. His research and leadership have contributed to more than 100 new investigational medicines and more than 25 approved medicines. Earlier in his career, he was a clinician at the Dana-Farber Cancer Institute and an associate professor at Harvard Medical School. He co-authored more than 300 scientific publications and numerous U.S. patent applications. He also co-founded five biotechnology companies. Dr. Bradner is a graduate of Harvard College and the University of Chicago Pritzker School of Medicine. He completed a residency in Medicine at Brigham & Women's Hospital, fellowships in Medical Oncology and Hematology at the Dana-Farber Harvard Cancer Center, and postdoctoral training in Chemistry and Chemical Biology at Harvard University.


 Session Abstract – PMWC 2027 Silicon Valley

Track 1: Next-Gen Tx - Jan 29 9.00 A.M.-4.30 P.M.


Track Chair:
Catriona Jamieson, UC San Diego

PMWC Award Ceremony
• Emmanuelle Charpentier, Max Planck (J. Craig Venter Visionary Award · Nobel Laureate)
• Jay Bradner, Amgen (Pioneer)
• Adrian Krainer, Cold Spring Harbor Laboratory (Luminary)
• Randy Schekman, UC Berkeley (Nobel Laureate, Pioneer)

Featured Speakers
• Emmanuelle Charpentier, Max Planck
• Randy Schekman, UC Berkeley
• Jay Bradner, Amgen
• Adrian Krainer, Cold Spring Harbor Laboratory
• Alexis C. Komor, UC San Diego
• Nicole Gaudelli, GV
• Rachel Haurwitz, Caribou Bio
• Gene Yeo, UC San Diego
• Timothy Yu, Boston Children's / Harvard
• Shicheng Guo, Arrowhead Pharmaceuticals
• Mark A. Kay, Stanford
• Niren Murthy, UC Berkeley
• Ben Deverman, Broad Institute
• Stanley Crooke, n-Lorem / Ionis

Programming Protein Fate
Molecular glues, degraders, and induced proximity crossing into medicines.

Genome Editing Beyond the First Wave
Base, prime, and CRISPR-enabled editing moving from correction to clinic.

RNA Editing, Splice Modulation & Programmable RNA
RNA editing, ASOs, and splice modulation with chemistry already reaching patients.

In Vivo Delivery & Vector Engineering
AAV, LNP, and next-generation vectors that decide what is treatable.

From N-of-1 to Platform
Evidence, CMC, regulation, and access for individualized genetic medicines.

Davos of Precision Medicine

PMWC 2027 Program

January 27–29, 2027 · Santa Clara Convention Center

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Preparing the full agendaFive scientific tracks. Three days of discovery.

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