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 Speaker Profile

PMWC PIONEER AWARD
From first WGS-treated patient to large-scale genomic programs

Ph.D., Vice President of Genomics Research and Head of Data Integration, Abbvie

Biography
Howard J. Jacob, Ph.D., brings decades of genome knowledge from academia and the clinical setting to address the current state of whole genome sequencing and its potential for both patients and those interested in learning more about their own DNA. Jacob is the Vice President and Head of Genomics and Data Integration at AbbVie and Distinguished Research Fellow and member of the scientific Governing Board. He joined AbbVie in January 2019 to lead one of the largest Genomics Research Center efforts in the field with access to over one million genomes and clinical data. In addition, he leads AbbVies RD-wide Data Integration Program (called Convergence) which brings together all types of data to create knowledge to solve and ultimately improve treatment for patients. The Convergence team recently launched the AbbVie Research Collaborative, a health data platform that enables patients to share their health data with AbbVie researchers to help advance the development of new medicines.Jacob earned his Ph.D. at the university of Iowa and then completed a post-doctorate with Eric Lander and Victor Dzai at MIT, Harvard, and Stanford. Prior to his work at AbbVie, he led the clinical teams at the worlds first stand-alone genomic medicine clinic, as well as a whole genome clinical sequencing lab. Jacob has published over 250 peer-reviewed articles. He founded four companies and is on the advisory boards for numerous academic and commercial organizations.As a pioneer and leader in genomics, in 2009, Howard and his team at the Medical College of Wisconsin were the first in the world to use genomic sequencing to save the life of a patient, Nicholas Volker. Nicholas story was highlighted in a Pulitzer Prize winning series in the Milwaukee Journal Sentinel.


 Session Abstract – PMWC 2026 Silicon Valley

Track 4: Integrated PM - March 5 9.00 A.M.-5.00 P.M.


Track Chair:
Burns Blaxall

PMWC Award Ceremony
• Euan Ashley, Stanford
• Jeffrey R. Balser, Vanderbilt
• Howard J. Jacob, Abbvie

Precision Medicine at Scale: Lessons from Vanderbilt
• Jeffrey R. Balser, Vanderbilt

From First Patient to a Million Genomes
• Chair: Howard J. Jacob, Abbvie
• Jeffrey R. Balser, Vanderbilt
• Euan Ashley, Stanford

Keynote: AI and Data-Driven Individual Health: Optimizing Wellness, Preventing Disease and Empowering Precision Medicine
• Lee Hood, Phenome Health

Keys to successful implementation of a Precision Medicine Program
• Chair: Howard McLeod, GeneDx
• Kevan Simms, Ochsner Health
• Chris Lunt, NIH

Key players in successful implementation – Beyond Oncology
• Chair: Damon Hostin, Illumina
• Shaista Malik, UC Irvine
• David E. Lanfear, Henry Ford Health
• Oren Caspi, Rambam

Precision Medicine at Scale: Lessons from a Statewide Genomic Initiative
• Chair: Premal Shah, MyOme
• Niall Lennon, Broad Clinical Labs

Integrating Multi-Modal Biology into Precision Care Pathways: A Systems Framework for Scalable Implementation
• K V Venkatesh, IIT Mumbai

Fireside Chat: From $/Gb to Outcomes: Simplifying Genomics for Health Systems
• Jacob Thaysen, Illumina

Achieving Comprehensive Precision Medicine
• Chair: Burns Blaxall
• Trish Brown, GeneDx
• Charles Sailey, Molecular Testing Labs
• Sarah Hersey, BMS

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