Speaker Profile

PMWC PIONEER AWARD
Uncovered sirtuin/NAD⁺ aging pathways and advanced epigenetic rejuvenation

Ph.D., Professor, Harvard

Biography
David A. Sinclair, A.O., Ph.D. is considered one of the world’s most influential scientists and a leading figure in the study of human longevity. He is a tenured Professor of Genetics at Harvard Medical School (Boston, MA, USA) and Co-Founder & Co-Chief Editor of the scientific journal Aging. Professor Sinclair’s pioneering work in genetics and aging biology has fundamentally shaped the world’s understanding of mechanisms of aging and age-related diseases. He is best known for his research on the molecular biology of aging, particularly the role of sirtuins, NAD+ metabolism, and epigenetic changes in regulating the aging process. In 2020, the Sinclair Lab reported successful use of cellular reprogramming to safely reverse aging in mammals, which they showed could cure blindness in animal models. Professor Sinclair served as Founding Director of the Glenn Center for Biology of Aging Research at Harvard Medical School from 2004 – 2023 and has published over 400 articles that have been cited ~100,000 times. He is the inventor on more than 50 patents and has co-founded over a dozen successful companies including MetroBiotech, EdenRoc Sciences, Fully Aligned Company, and Life Biosciences. Professor Sinclair is the New York Times bestselling author of Lifespan: Why We Age-And Why We Don’t Have To and the host of the Lifespan with Dr. David Sinclair podcast, a #1 show on Apple that provides health and science education. Among over 35 career awards, Professor Sinclair has been recognized as one of TIME Magazine’s 100 Most Influential People In The World, one of TIME’s 50 Most Influential People In Health Care, received the Pioneer Award from the Director of the NIH, The Noble Genius Prize from The World Forum, and was appointed by Queen Elizabeth’s representative as Officer of the Order of Australia(A.O.) for his contributions to scientific research, science communication, and national security.


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