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 Speaker Profile

Professor, Harvard

Biography
David A. Sinclair, A.O., Ph.D. is considered one of the worlds mostinfluential scientists and a leading figure in the study of humanlongevity. He is a tenured Professor of Genetics at Harvard Medical School(Boston, MA, USA) and Co-FounderCo-Chief Editor of the scientificjournal Aging.Professor Sinclairs pioneering work in genetics and aging biology hasfundamentally shaped the worlds understanding of mechanisms of aging andage-related diseases. He is best known for his research on the molecularbiology of aging, particularly the role of sirtuins, NAD+ metabolism, andepigenetic changes in regulating the aging process. In 2020, the SinclairLab reported successful use of cellular reprogramming to safely reverseaging in mammals, which they showed could cure blindness in animal models.Professor Sinclair served as Founding Director of the Glenn Center forBiology of Aging Research at Harvard Medical School from 20042023 andhas published over 400 articles that have been cited 100,000 times. He isthe inventor on more than 50 patents and has co-founded over a dozensuccessful companies including MetroBiotech, EdenRoc Sciences, FullyAligned Company, and Life Biosciences.Professor Sinclair is the New York Times bestselling author of Lifespan:Why We Age-And Why We Dont Have To and the host of the Lifespan with Dr.David Sinclair podcast, a 1 show on Apple that provides health and scienceeducation.Among over 35 career awards, Professor Sinclair has been recognized as oneof TIME Magazines 100 Most Influential People In The World, one of TIMEs50 Most Influential People In Health Care, received the Pioneer Award fromthe Director of the NIH, The Noble Genius Prize from The World Forum, andwas appointed by Queen Elizabeths representative as Officer of the Orderof Australia(A.O.) for his contributions to scientific research, sciencecommunication, and national security.


 Session Abstract – PMWC 2026 Silicon Valley

Track 4: Integrated PM - March 6 9.00 A.M.-4.15 P.M.


Track Chair:
Michael Goldman, SFSU

PMWC Award Ceremony
• David Sinclair, Harvard
• Steve Horvath, UCLA
• Nir Barzilai, Albert Einstein College of Medicine

AI-Driven Biomarkers to Quantify Aging
• Chair: Alex Zhavoronkov, Insilico Medicine
• Luigi Ferrucci, NIH
• Sara Hägg, Karolinska Institutet
• Steve Horvath, UCLA

Epigenetic Aging Signatures in Large Human Cohorts
• Varun Dwaraka, Trudiagnostic

AI Systems for Personalized Longevity: How Biomarkers Translate into Actionable Interventions
• Sherry Zhang, Buck Institute
• Nathan Price, THORNE
• Ranjan Sinha, digbi Health

Epigenetic Rejuvenation & Delivery for Clinical Translation
• Ryan (Yuancheng) Lu, Whitehead Institute/MIT
• David Sinclair, Harvard

Clinical Trial Design & Functional Endpoints for Healthspan
• Nir Barzilai, Albert Einstein College of Medicine

Precision Aging & Longevity: Limited Lifespan Evidence, Vanishing Blue Zones, and Payer ROI
• S. Jay Olshansky, University of Illinois
• Michael Gurven, UC Santa Barbara

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